Comparative analysis of nucleic acid sequences by their general constraints | Zendy

David J. Lipman | Zendy; Jacob V. Maizel | Zendy

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Comparative analysis of nucleic acid sequences by their general constraints

Author(s) -

David J. Lipman,

Jacob V. Maizel

Publication year - 1982

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/10.8.2723

Subject(s) - biology , intron , nucleic acid , subsequence , genetics , gene , computational biology , conserved sequence , dna , sequence (biology) , coding (social sciences) , sequence analysis , coding region , base sequence , mathematics , statistics , mathematical analysis , bounded function

We describe two measures of a nucleic acid sequence, derived from Information Theory, which characterize the constraints toward nonuniform base composition, and the constraints on the ordering of the bases. These two measures distinguish extra-chromosomal coding sequences from all other coding sequences examined. The two measures separate eukaryotic coding sequences into two groups: those with introns and those without introns. We have also found a relationship between the general constraints of a subsequence and its degree of conservation in related genes.

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