The high mobility group proteins, HMG 14 and 17, do not prevent the formation of chromatin higher order structure | Zendy

James D. McGhee | Zendy; Donald C. Rau | Zendy; Gary Felsenfeld | Zendy

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The high mobility group proteins, HMG 14 and 17, do not prevent the formation of chromatin higher order structure

Author(s) -

James D. McGhee,

Donald C. Rau,

Gary Felsenfeld

Publication year - 1982

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/10.6.2007

Subject(s) - chromatin , high mobility group , biology , hmg coa reductase , non histone protein , circular dichroism , gene , microbiology and biotechnology , genetics , biophysics , biochemistry , enzyme , reductase

The high mobility group proteins, HMG 14 and 17, have been associated with the chromatin of active genes (refs 1-8), although how they function is not known. We use sedimentation and electric dichroism to investigate the effect of HMG 14 and 17 on the condensation of chicken erythrocyte chromatin into higher order structure. We find no evidence that excess HMG 14 and 17 induce an extended configuration, either in bulk chromatin or in the chromatin of the chicken beta-globulin gene.

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