Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes | Zendy

Guido C. F. Pedrali Noy | Zendy; Leda Dalprà | Zendy; Antonia M. Pedrini | Zendy; Giovanni Ciarrocchi | Zendy; Elena Giulotto | Zendy; Fiorella Nuzzo | Zendy; Arturo Falaschi | Zendy

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Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes

Author(s) -

Guido C. F. Pedrali Noy,

Leda Dalprà,

Antonia M. Pedrini,

Giovanni Ciarrocchi,

Elena Giulotto,

Fiorella Nuzzo,

Arturo Falaschi

Publication year - 1974

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/1.9.1183

Subject(s) - biology , dna ligase , dna polymerase , dna , enzyme , thymidine , dna synthesis , dna replication , microbiology and biotechnology , dna ligases , stimulation , endonuclease , dna clamp , dna polymerase ii , dna polymerase i , biochemistry , polymerase chain reaction , gene , reverse transcriptase , neuroscience

The stimulation of human lymphocytes with phytohaemoagglutinin induces the appearance or increase of several enzymes of DNA metabolism [Pedrini etal., Biochem. Biophys. Res. Comm., 47:1221(1972)]. With long times of stimulation, two phenomena are observed; an increase in the levels of DNA polymerase, of a DNase acting on single-stranded DNA, and of an endonuclease, occurring between the third and fourth day, in parallel with a wave of DNA synthesis;a second wave of increase of the same enzymes and of DNA ligase,occurring between the fifth and eight day when the DNA replication rate, as measured by thymidine-pulses, has decreased to values close to the background.

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