Unpaired bases in superhelical DNA: kinetic evidence | Zendy

Robert J. K. Jacob | Zendy; Jacob Lebowitz | Zendy; Morton P. Printz | Zendy

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Unpaired bases in superhelical DNA: kinetic evidence

Author(s) -

Robert J. K. Jacob,

Jacob Lebowitz,

Morton P. Printz

Publication year - 1974

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/1.4.549

Subject(s) - biology , dna , biophysics , formaldehyde , molecule , twist , double stranded , biochemistry , stereochemistry , chemistry , geometry , mathematics , organic chemistry

Kinetic analysis of the early, fast reaction of superhelical DNA with formaldehyde reveals that this region or regions is 56% "single strand like" in character. Hydrogen-tritium exchange studies coupled with other considerations show that this reaction is not due to a difference in conformational motility between form I and form II molecules, but is due to unpaired or weakly hydrogen bonded, localized region(s) of the form I allomorph of circular DNA.

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