Brca2 (XRCC11) deficiency results in enhanced mutagenesis | Zendy

Maria Kraakman-van der Zwet | Zendy

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Brca2 (XRCC11) deficiency results in enhanced mutagenesis

Author(s) -

Maria Kraakman-van der Zwet

Publication year - 2003

Publication title -

mutagenesis

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.723

H-Index - 91

eISSN - 1464-3804

pISSN - 0267-8357

DOI - 10.1093/mutage/geg032

Subject(s) - mutagenesis , mutant , chinese hamster , biology , genetics , mutation , mutation rate , microbiology and biotechnology , hypoxanthine guanine phosphoribosyltransferase , wild type , genome instability , gene , cancer research , cell culture , dna damage , dna

Brca2 deficiency is associated with chromosomal instability and an increased risk of breast and other cancers. To examine the effect of Brca2 deficiency on mutagenesis, we measured the spontaneous mutation rate at the endogenous hprt gene in the Brca2-deficient Chinese hamster cell mutant V-C8. A 4.3-fold increase was found in the spontaneous mutation rate at this locus, indicating the importance of Brca2 in the prevention of mutagenesis. In addition, following exposure to IR, a 2.3-fold increase in mutant frequency per Gy was found for V-C8 in comparison with wild-type V79. These data suggest a potential risk from ionizing radiation for BRCA2 patients.

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