Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B1 | Zendy

Regina Montero | Zendy; L. Serrano | Zendy; Víctor M. Dávila | Zendy; Akio Ito | Zendy; A. Plancarte | Zendy

Open Access

Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B1

Author(s) -

Regina Montero,

L. Serrano,

Víctor M. Dávila,

Akio Ito,

A. Plancarte

Publication year - 2003

Publication title -

mutagenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.723

H-Index - 91

eISSN - 1464-3804

pISSN - 0267-8357

DOI - 10.1093/mutage/18.2.211

Subject(s) - genotoxicity , aflatoxin , isozyme , pyrene , cyclophosphamide , carcinogen , gene isoform , benzo(a)pyrene , chemistry , biology , pharmacology , microbiology and biotechnology , toxicity , biochemistry , enzyme , gene , genetics , food science , chemotherapy , organic chemistry

Infection of rat liver by Taenia taeniformis metacestodes produced an increase in total CYP450 content and induced activity of the CYP1A1, CYP2B1 and COH isoforms. Variations in activity and p450 total content were found with increasing time of infection. During increased activity of p450 isoforms, rats were challenged with carcinogens metabolized by the mentioned isozymes and an increased amount of genotoxic damage was found when benzo[a] pyrene, cyclophosphamide and aflatoxin B(1) were used. No change was seen in CYP2E1 activity. These results support previous findings regarding an increased susceptibility to genotoxic damage of infected organisms.

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