Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine | Zendy

Taraknath Chatterjee | Zendy; Amitabha Muhkopadhyay | Zendy; K.A. Khan | Zendy; Ashok K. Giri | Zendy

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Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine

Author(s) -

Taraknath Chatterjee,

Amitabha Muhkopadhyay,

K.A. Khan,

Ashok K. Giri

Publication year - 1998

Publication title -

mutagenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.723

H-Index - 91

eISSN - 1464-3804

pISSN - 0267-8357

DOI - 10.1093/mutage/13.6.619

Subject(s) - amodiaquine , primaquine , sister chromatid exchange , chloroquine , in vivo , pharmacology , ames test , chemistry , genotoxicity , chromosome aberration , salmonella , malaria , biology , in vitro , toxicity , biochemistry , chromosome , immunology , genetics , organic chemistry , bacteria , gene

Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine, were assessed in the Ames mutagenicity assay (in strains TA97a, TA100, TA102 and TA104) and in vivo sister chromatid exchange (SCE) and chromosome aberration (CA) assays in bone marrow cells of mice. These are the most commonly used antimalarial drugs available at present throughout the world. The results of the bacterial mutagenicity assays showed a very weak mutagenic effect of all three drugs in Salmonella strains TA97a and TA100 both with and without S9 mix and in TA104 only with S9 mix. The results of the in vivo SCE and CA assays indicate that these three drugs are genotoxic in bone marrow cells of mice.

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