Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics? | Zendy

Daniela Gerovska | Zendy; Marcos J. AraúzoBravo | Zendy

Open Access

Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?

Author(s) -

Daniela Gerovska,

Marcos J. AraúzoBravo

Publication year - 2016

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/gav072

Subject(s) - biology , dna methylation , microbiology and biotechnology , epiblast , methyltransferase , reprogramming , genetics , transcription factor , embryoid body , epigenetics , dna methyltransferase , transcriptome , epigenomics , germ cell , embryonic stem cell , embryo , methylation , induced pluripotent stem cell , cell , gene expression , dna , embryogenesis , gene , gastrulation

Does primordial germ cell (PGC) activation start before mouse embryo implantation, and does the possible regulation of the DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l) by transcription factor AP-2, gamma (TCFAP2C) have a role in this activation and in the primitive endoderm (PE)-epiblast (EPI) lineage specification?

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