Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool—technicalities and possible risks | Zendy

Lynsey M. Cree | Zendy; Pasqualino Loi | Zendy

Open Access

Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool—technicalities and possible risks

Author(s) -

Lynsey M. Cree,

Pasqualino Loi

Publication year - 2014

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/gau082

Subject(s) - biology , mitochondrial dna , mitochondrial disease , risk analysis (engineering) , genetics , bioinformatics , computational biology , medicine , gene

Mitochondrial DNA (mtDNA) mutations are a relatively common cause of progressive disorders that can be severe or even life-threatening. There is currently no cure for these disorders; therefore recent research has been focused on attempting to prevent the transmission of these maternally inherited mutations. Here we highlight the challenges of understanding the transmission of mtDNA diseases, discuss current genetic management options and explore the use of germ-line reconstruction technologies to prevent mtDNA diseases. In particular we discuss their potential, indications, limitations and possible safety concerns.

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