A new tool to generate transgenic rats using female germline stem cells from post-natal ovaries | Zendy

Yuchun Pan | Zendy

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A new tool to generate transgenic rats using female germline stem cells from post-natal ovaries

Author(s) -

Yuchun Pan

Publication year - 2014

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/gau017

Subject(s) - biology , allantois , germline , embryo , medicine , oocyte , endocrinology , ovary , yolk sac , andrology , microbiology and biotechnology , transgene , gonadal ridge , stem cell , embryonic stem cell , sexual differentiation , embryogenesis , genetics , gene

Primordial germ cells (PGCs) are the precursors of reproductive gametes. They were first identified in the posterior region of embryos at the angle between the allantois and the wall of the yolk sac, and were shown to subsequently migrate into the forming gonadal ridges in early mouse and human embryos of both sexes (Eddy et al., 1981; Bendel-Stenzel et al., 1998). PGCs will eventually differentiate into oogonia/oocytes in the female mammals. At birth, ovaries are filled with primordial follicles, which are differentiated from PGCs/oogonia (De Felici, 2010; De Felici and Barrios, 2013).

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