Nucleolar transplantation in oocytes and zygotes: challenges for further research | Zendy

J. Fulka | Zendy

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Nucleolar transplantation in oocytes and zygotes: challenges for further research

Author(s) -

J. Fulka

Publication year - 2009

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/gap088

Subject(s) - pronucleus , biology , zygote , nucleolus , germinal vesicle , embryo , microbiology and biotechnology , oocyte , transplantation , embryonic stem cell , organelle , embryogenesis , andrology , genetics , gene , nucleus , medicine

In germinal vesicles of immature mammalian oocytes, including humans, as well as in pronuclei in 1-cell stage embryos, prominent nuclear organelles, nucleoli, can be easily detected even under a relatively low magnification. In humans, it has been clearly documented that their number, position and distribution in pronuclei can be used as an indicator of embryonic developmental potential. In the light of some recent experiments showing the feasibility of nucleolar manipulation we discuss here if these new approaches can be used to rescue those embryos with abnormal pronuclear nucleolar patterns.

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