Potential influence of COVID-19/ACE2 on the female reproductive system | Zendy

Jing Yan | Zendy; Run-Qian Li | Zendy; Haoran Wang | Zendy; Hao Chen | Zendy; Ya-Bin Liu | Zendy; Yang Gao | Zendy; Fei Chen | Zendy

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Potential influence of COVID-19/ACE2 on the female reproductive system

Author(s) -

Jing Yan,

Run-Qian Li,

Haoran Wang,

Hao Chen,

Ya-Bin Liu,

Yang Gao,

Fei Chen

Publication year - 2020

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/gaaa030

Subject(s) - biology , covid-19 , betacoronavirus , coronavirus infections , reproductive biology , virology , medicine , genetics , embryo , embryogenesis , outbreak , disease , infectious disease (medical specialty)

The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2.

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