Modulation of indoleamine 2,3-dioxygenase by interferon-gamma in human placental chorionic villi | Zendy

Yoshiki Kudo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Modulation of indoleamine 2,3-dioxygenase by interferon-gamma in human placental chorionic villi

Author(s) -

Yoshiki Kudo

Publication year - 2000

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/6.4.369

Subject(s) - indoleamine 2,3 dioxygenase , biology , interferon , interferon gamma , chorionic villi , microbiology and biotechnology , endocrinology , placenta , tryptophan , cytokine , biochemistry , immunology , fetus , pregnancy , genetics , amino acid

The effect of interferon-gamma on indoleamine 2,3-dioxygenase, a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi. The activity of indoleamine 2,3-dioxygenase was markedly stimulated by interferon-gamma in a time- and concentration-dependent manner. Interferon-alpha and interferon-beta also showed a slight stimulatory effect on indoleamine 2,3-dioxygenase activity. The level of indoleamine 2,3-dioxygenase mRNA expression (determined by reverse transcription-polymerase chain reaction) was also enhanced by interferon-gamma. Interleukin-4 showed a dose-dependent inhibitory effect on interferon-gamma-induced stimulation of indoleamine 2,3-dioxygenase activity and mRNA expression.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research