Molecular interactions during pregnancy | Zendy

Maria de Lourdes Brizot | Zendy; Eric Jauniaux | Zendy; Andrew T. McKie | Zendy; Farzin Farzaneh | Zendy; K. H. Nicolaides | Zendy

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Molecular interactions during pregnancy

Author(s) -

Maria de Lourdes Brizot,

Eric Jauniaux,

Andrew T. McKie,

Farzin Farzaneh,

K. H. Nicolaides

Publication year - 1996

Publication title -

molecular human reproduction

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/2.6.463

Subject(s) - trisomy , biology , gestation , messenger rna , andrology , human chorionic gonadotropin , placenta , endocrinology , pregnancy , medicine , aneuploidy , protein subunit , gene , fetus , genetics , hormone , chromosome

The placental expression of human chorionic gonadotrophin (HCG) I- and beta-subunits was investigated in eight pregnancies presenting with trisomy 18 and in 30 normal pregnancies at 11-15 weeks gestation. In the control group, the median densitometric scores of placental beta-HCG and I-HCG mRNA were 1.23 and 1.74 respectively. In the trisomy 18 group the median beta-HCG mRNA was significantly lower (0.16, Z = 2.29, P < 0.05) but alpha-HCG [0.60, Z = 1.75, P = 0.08) was not significantly different from normal. These findings suggest that in trisomy 18 the decrease in maternal serum concentration of HCG subunits results from an impairment in the transcription of the corresponding gene which affects the beta subunit to a greater extent than the I subunit.

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