Preimplantation embryology | Zendy

Tracy L. Rankin | Zendy; Jurrien Dean | Zendy

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Preimplantation embryology

Author(s) -

Tracy L. Rankin,

Jurrien Dean

Publication year - 1996

Publication title -

molecular human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.143

H-Index - 122

eISSN - 1460-2407

pISSN - 1360-9947

DOI - 10.1093/molehr/2.11.889

Subject(s) - zona pellucida , polyspermy , biology , zona pellucida glycoprotein , human fertilization , embryo , zygote , microbiology and biotechnology , oocyte , genetics , andrology , embryogenesis , medicine

The zona pellucida is an extracellular matrix surrounding growing oocytes, ovulated eggs and the preimplantation embryo. After mediating the relatively species-specific events of fertilization, the zona pellucida provides a post-fertilization block to polyspermy and protects the growing embryo as it passes down the oviduct. The genes that encode the three zona pellucida proteins (ZP1, ZP2, ZP3) have been characterized in mouse and human. The ability to genetically manipulate the zona pellucida genes in mouse models has enhanced our knowledge of zona pellucida structure and function in vivo and may translate into a better understanding of human fertility.

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