Molecular Biology and Evolution of Cancer: From Discovery to Action | Zendy

Jason A. Somarelli | Zendy; Heather L. Gardner | Zendy; Vincent L. Cannataro | Zendy; Ella F Gunady | Zendy; Amy M. Boddy | Zendy; Norman Johnson | Zendy; Jeffrey Nicholas Fisk | Zendy; Stephen G. Gaffney | Zendy; Jeffrey H. Chuang | Zendy; Sheng Li | Zendy; Francesca D. Ciccarelli | Zendy; Anna R. Panchenko | Zendy; Kate Megquier | Zendy; Sudhir Kumar | Zendy; Alex Dornburg | Zendy; James DeGregori | Zendy; Jeffrey P. Townsend | Zendy

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Molecular Biology and Evolution of Cancer: From Discovery to Action

Author(s) -

Jason A. Somarelli,

Heather L. Gardner,

Vincent L. Cannataro,

Ella F Gunady,

Amy M. Boddy,

Norman Johnson,

Jeffrey Nicholas Fisk,

Stephen G. Gaffney,

Jeffrey H. Chuang,

Sheng Li,

Francesca D. Ciccarelli,

Anna R. Panchenko,

Kate Megquier,

Sudhir Kumar,

Alex Dornburg,

James DeGregori,

Jeffrey P. Townsend

Publication year - 2019

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msz242

Subject(s) - biology , action (physics) , cancer , process (computing) , ecological niche , cognitive science , suite , niche construction , computational biology , evolutionary biology , ecology , computer science , genetics , psychology , history , physics , archaeology , habitat , operating system , quantum mechanics

Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.

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