Nonequilibrium Neutral Theory for Hitchhikers | Zendy

Yoko Satta | Zendy; Naoko T. Fujito | Zendy; Naoyuki Takahata | Zendy

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Nonequilibrium Neutral Theory for Hitchhikers

Author(s) -

Yoko Satta,

Naoko T. Fujito,

Naoyuki Takahata

Publication year - 2018

Publication title -

molecular biology and evolution

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msy093

Subject(s) - selective sweep , biology , variation (astronomy) , population , selection (genetic algorithm) , non equilibrium thermodynamics , allele , genetics , evolutionary biology , gene , demography , physics , quantum mechanics , artificial intelligence , sociology , astrophysics , computer science , haplotype

Selective sweep is a phenomenon of reduced variation at presumably neutrally evolving sites (hitchhikers) in the genome that is caused by the spread of a selected allele at a linked focal site, and is widely used to test for action of positive selection. Nonetheless, selective sweep may also provide an unprecedented opportunity for studying nonequilibrium properties of the neutral variation itself. We have demonstrated this possibility in relation to ancient selective sweep for modern human-specific changes and ongoing selective sweep for local population-specific changes.

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