Open AccessNo X-Chromosome Dosage Compensation in Human Proteomes
Author(s) -
Xiaoshu Chen,
Jianzhi Zhang
Publication year - 2015
Publication title -
molecular biology and evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.637
H-Index - 218
eISSN - 1537-1719
pISSN - 0737-4038
DOI - 10.1093/molbev/msv036
Subject(s) - dosage compensation , biology , autosome , marsupial , x chromosome , chromosome , proteome , messenger rna , downregulation and upregulation , gene , genetics , human proteome project , computational biology , proteomics , zoology
The X and Y chromosomes of placental and marsupial mammals originated from a pair of autosomes. Ohno proposed that the expression levels of X-linked genes must have been doubled in males to compensate for the degeneration of their Y homologs. Recent mRNA sequencing experiments, however, found at most weak or infrequent X-chromosome dosage compensation. Nonetheless, dosage compensation need not occur at the mRNA level, because ultimately it is the protein concentration that matters. Analyzing human proteomic data from 22 tissues, we here report that X upregulation is absent at the protein level, indicating that Ohno's hypothesis is also invalid at the protein level.
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