Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction | Zendy

Kyriacos Felekkis | Zendy; Konstantinos Voskarides | Zendy; H. Dweep | Zendy; Carsten Sticht | Zendy; N. Gretz | Zendy; Constantinos Deltas | Zendy

Open Access

Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction

Author(s) -

Kyriacos Felekkis,

Konstantinos Voskarides,

H. Dweep,

Carsten Sticht,

N. Gretz,

Constantinos Deltas

Publication year - 2011

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msr078

Subject(s) - biology , copy number variation , microrna , gene , in silico , genetics , genome , gene dosage , computational biology , gene expression , evolutionary biology

MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity.

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