Alu Monomer Revisited: Recent Generation of Alu Monomers | Zendy

Kenji K. Kojima | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Alu Monomer Revisited: Recent Generation of Alu Monomers

Author(s) -

Kenji K. Kojima

Publication year - 2010

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msq218

Subject(s) - biology , alu element , set (abstract data type) , evolutionary biology , genetics , computational biology , gene , computer science , human genome , genome , programming language

Alu is a predominant short interspersed element (SINE) family in the human genome and consists of two monomer units connected by an A-rich linker. At present, dimeric Alu elements are active in humans, but Alu monomers are present as fossilized sequences. A comparative genome analysis of human and chimpanzee genomes revealed eight recent insertions of Alu monomers. One of them was a retroposed product of another Alu monomer with 3' transduction. Further analysis of 1,404 loci of the Alu monomer in the human genome revealed that some Alu monomers were recently generated by recombination between the internal and 3' A-rich tracts inside of dimeric Alu elements. The data show that Alu monomers were generated by 1) retroposition of other Alu monomers and 2) recombination between two A-rich tracts.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research