Domain Stealing by Receptors in a Protein Transport Complex | Zendy

Joanne M. Hulett | Zendy; Peter Walsh | Zendy; Trevor Lithgow | Zendy

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Domain Stealing by Receptors in a Protein Transport Complex

Author(s) -

Joanne M. Hulett,

Peter Walsh,

Trevor Lithgow

Publication year - 2007

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msm126

Subject(s) - biology , saccharomyces cerevisiae , mitochondrion , microbiology and biotechnology , yeast , saccharomyces , receptor , biogenesis , transport protein , genetics , gene

The mitochondrion is an essential cellular compartment in eukaryotes. The mitochondrial proteins Tom20 and Tom22 are receptors that ensure recognition and binding of proteins imported for mitochondrial biogenesis. Comparison of the sequence for the Tom20 and Tom22 subunits in the yeasts Saccharomyces cerevisiae and Saccharomyces castellii, show a rare case of domain stealing, where in Saccharomyces castellii Tom22 has lost an acidic domain, and Tom20 has gained one. This example of domain stealing is a snapshot of evolution in action and provides excellent evidence that Tom20 and Tom22 are subunits of a single, composite receptor that binds precursor proteins for import into mitochondria.

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