No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males | Zendy

Luı́sa Pereira | Zendy; João Gonçalves | Zendy; Ricardo FrancoDuarte | Zendy; Júlia Silva | Zendy; Tiago Rocha | Zendy; Christiane Arnold | Zendy; Martin Richards | Zendy; Vincent Macaulay | Zendy

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No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males

Author(s) -

Luı́sa Pereira,

João Gonçalves,

Ricardo FrancoDuarte,

Júlia Silva,

Tiago Rocha,

Christiane Arnold,

Martin Richards,

Vincent Macaulay

Publication year - 2007

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msm004

Subject(s) - biology , mitochondrial dna , sperm , sperm motility , genetics , evolutionary biology , andrology , gene , medicine

The first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

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