Systematically Assessing the Influence of 3-Dimensional Structural Context on the Molecular Evolution of Mammalian Proteomes | Zendy

Sun Shim Choi | Zendy; Eric J. Vallender | Zendy; Bruce T. Lahn | Zendy

Open Access

Systematically Assessing the Influence of 3-Dimensional Structural Context on the Molecular Evolution of Mammalian Proteomes

Author(s) -

Sun Shim Choi,

Eric J. Vallender,

Bruce T. Lahn

Publication year - 2006

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msl086

Subject(s) - biology , constraint (computer aided design) , context (archaeology) , computational biology , proteome , amino acid residue , residue (chemistry) , intramolecular force , protein structure , evolutionary biology , biochemistry , peptide sequence , gene , stereochemistry , chemistry , mechanical engineering , paleontology , engineering

The 3-dimensional (3D) structural context of amino acid residues in a protein could significantly impact the level of selective constraint on the residues. Here, by analyzing 767 mammalian proteins, we systematically investigate how various 3D structural contexts influence selective constraint. The structural contexts we examined include solvent accessibility, secondary structure, and intramolecular residue-residue interactions. Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint.

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