Mutations Induced by Ancient DNA Extracts? | Zendy

David Serre | Zendy; Michael Hofreiter | Zendy; Svante Pääbo | Zendy

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Mutations Induced by Ancient DNA Extracts?

Author(s) -

David Serre,

Michael Hofreiter,

Svante Pääbo

Publication year - 2004

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msh139

Subject(s) - biology , ancient dna , dna , genetics , mutation , dna sequencing , nucleotide , dna extraction , evolutionary biology , gene , polymerase chain reaction , population , demography , sociology

We have investigated whether some factor in ancient DNA extracts induces site-specific mutations in modern DNA. We find no evidence for higher mutation rates when extracts from three different Pleistocene mammals are added to modern DNA than when water or extraction blanks are added. We also fail to find evidence that any such factor affects ancient DNA sequences determined from the same extracts. This as well as the patterns of nucleotide substitutions seen in DNA sequences determined from hundreds of other specimens leads us to doubt that a previously unknown mutagenic factor can be a general feature of extracts from old tissues.

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