Selection on Coding Regions Determined Hox7 Genes Evolution | Zendy

Mario A. Fares | Zendy

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Selection on Coding Regions Determined Hox7 Genes Evolution

Author(s) -

Mario A. Fares

Publication year - 2003

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msg222

Subject(s) - biology , hox gene , gene , gene duplication , evolutionary biology , vertebrate , negative selection , genetics , selection (genetic algorithm) , body plan , positive selection , molecular evolution , functional divergence , phylogenetics , gene family , genome , gene expression , artificial intelligence , computer science

The important role of Hox genes in determining the regionalization of the body plan of the vertebrates makes them invaluable candidates for evolutionary analyses regarding functional and morphological innovation. Gene duplication and gene loss led to a variable number of Hox genes in different vertebrate lineages. The evolutionary forces determining the conservation or loss of Hox genes are poorly understood. In this study, we show that variable selective pressures acted on Hox7 genes in different evolutionary lineages, with episodes of positive selection occurring after gene duplications. Tests for functional divergence in paralogs detected significant differentiation in a region known to modulate HOX7 protein activity. Our results show that both positive and negative selection on coding regions are influencing Hox7 genes evolution.

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