Open AccessProtein Conformational Space at the Edge of Allostery: Turning a Nonallosteric Malate Dehydrogenase into an “Allosterized” Enzyme Using Evolution-Guided Punctual Mutations
Author(s) -
Antonio Iorio,
Céline BrochierArmanet,
Caroline Mas,
Fabio Sterpone,
Dominique Madern
Publication year - 2022
Publication title -
molecular biology and evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.637
H-Index - 218
eISSN - 1537-1719
pISSN - 0737-4038
DOI - 10.1093/molbev/msac186
Subject(s) - allosteric regulation , biology , malate dehydrogenase , mutagenesis , mutant , conformational isomerism , allosteric enzyme , directed evolution , biochemistry , molecular dynamics , dehydrogenase , protein structure , protein dynamics , biophysics , enzyme , gene , chemistry , molecule , computational chemistry , organic chemistry
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