Open AccessGiant Viruses Encode Actin-Related Proteins
Author(s) -
Violette Da Cunha,
Morgan Gaïa,
Hiroyuki Ogata,
Olivier Jaillon,
Tom O. Delmont,
Patrick Forterre
Publication year - 2022
Publication title -
molecular biology and evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.637
H-Index - 218
eISSN - 1537-1719
pISSN - 0737-4038
DOI - 10.1093/molbev/msac022
Subject(s) - biology , giant virus , actin , genome , actin cytoskeleton , horizontal gene transfer , gene , cytoskeleton , evolutionary biology , phylogenetic tree , genetics , microbiology and biotechnology , cell
The emergence of the eukaryotic cytoskeleton is a critical yet puzzling step of eukaryogenesis. Actin and actin-related proteins (ARPs) are ubiquitous components of this cytoskeleton. The gene repertoire of the Last Eukaryotic Common Ancestor (LECA) would have therefore harbored both actin and various ARPs. Here, we report the presence and expression of actin-related genes in viral genomes (viractins) of some Imitervirales, a viral order encompassing the giant Mimiviridae. Phylogenetic analyses suggest an early recruitment of an actin-related gene by viruses from ancient protoeukaryotic hosts before the emergence of modern eukaryotes, possibly followed by a back transfer that gave rise to eukaryotic actins. This supports a coevolutionary scenario between pre-LECA lineages and their viruses, which could have contributed to the emergence of the modern eukaryotic cytoskeleton.