Cervical Cancer Markers: Epigenetics and microRNAs | Zendy

Vishuda Laengsri | Zendy; Usanee Kerdpin | Zendy; Chotiros Plabplueng | Zendy; Lertyot Treeratanapiboon | Zendy; Pornlada Nuchnoi | Zendy

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Cervical Cancer Markers: Epigenetics and microRNAs

Author(s) -

Vishuda Laengsri,

Usanee Kerdpin,

Chotiros Plabplueng,

Lertyot Treeratanapiboon,

Pornlada Nuchnoi

Publication year - 2017

Publication title -

laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.332

H-Index - 28

eISSN - 1943-7730

pISSN - 0007-5027

DOI - 10.1093/labmed/lmx080

Subject(s) - microrna , epigenetics , cervical cancer , disease , cancer , pathogenesis , biology , medicine , bioinformatics , oncology , gene , genetics

Gynecologic malignant neoplasms are a severe health problem among female patients, of which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. Despite extensive attempts by researchers to solve the molecular mystery of CC, the mechanisms of its pathogenesis remain unclear. Tumor markers used in the clinical laboratory, such as squamous cell carcinoma (SCC), cancer antigen (CA)-125, and CA19-9, provide some help in diagnosing patients with CC. However, finding new molecular markers with high sensitivity and specificity is necessary. This review focuses on the role of epigenetic changes, particularly microRNAs (miRNAs), to CC. Several miRNAs that associated with CC potentially have the advantage of being early biomarkers. Moreover, altered serum miRNAs or single nucleotide polymorphisms in miRNA patterns may predict disease progression.

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