Open AccessA Case of a Newborn With Blocked RhD Antigen and HDFN
Author(s) -
Haijuan Wang,
Jian Chen,
Yongmei Jiang
Publication year - 2017
Publication title -
laboratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.332
H-Index - 28
eISSN - 1943-7730
pISSN - 0007-5027
DOI - 10.1093/labmed/lmx061
Subject(s) - titer , antigen , antibody , medicine , antibody titer , gestation , exchange transfusion , gestational age , rh isoimmunization , immunology , andrology , pregnancy , biology , fetus , genetics
A group O RhD-negative pregnant patient with anti-D antibody at titer 1:2048 delivered a baby boy by cesarean section at 38 + 6 weeks gestational age. The neonate typed as group O, but D antigen was at first uncertain. DAT and antibody screen of newborn were both positive. Various assays were used for D antigen determination. Ultimately, D antigen blocked by high-titer maternal anti-D antibody was confirmed. Total bilirubin of the newborn was 52.7 umol/L, and hemoglobin was 1.46 mg/dL. O RhD-negative red cells were used for an exchange transfusion.
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