Open AccessDNA Methylation of thehTERTGene in Breast Cancer Revisited: Diagnostic and Clinical Implications
Author(s) -
Shahla Masood,
Ehab A. ElGabry,
Chuhua Zhang,
Zhiqiang Wang
Publication year - 2016
Publication title -
laboratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.332
H-Index - 28
eISSN - 1943-7730
pISSN - 0007-5027
DOI - 10.1093/labmed/lmw043
Subject(s) - cpg site , breast cancer , dna methylation , methylation , cancer research , biology , cancer , biomarker , gene , pathology , oncology , medicine , gene expression , genetics
It is documented that in tumor cell lines, the hTERT gene exhibits prominent methylation at a CpG island rich region about -600 bp upstream of the transcription start site, but mixed or allelically absent around ±150 bp region. Given the potential clinical implications of the findings in breast cancer diagnostics, we set out to investigate if such findings are reproducible on primary surgically resected invasive breast carcinomas.
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