Association of DNA Methyltransferase 3B Promotor Polymorphism With Childhood Chronic Immune Thrombocytopenia | Zendy

Heba Gouda | Zendy; Nermine M. Kamel | Zendy; Safa Meshaal | Zendy

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Association of DNA Methyltransferase 3B Promotor Polymorphism With Childhood Chronic Immune Thrombocytopenia

Author(s) -

Heba Gouda,

Nermine M. Kamel,

Safa Meshaal

Publication year - 2016

Publication title -

laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.332

H-Index - 28

eISSN - 1943-7730

pISSN - 0007-5027

DOI - 10.1093/labmed/lmw040

Subject(s) - promoter , genetics , dna methyltransferase , immune system , polymorphism (computer science) , immune thrombocytopenia , methyltransferase , immunology , medicine , biology , genotype , dna , methylation , gene , antibody , gene expression

DNA methylation is an epigenetic process that refers to chromatin-based mechanisms in the regulation of gene expression without DNA alternation. It is mediated by DNA methyltransferases (DNMTs). The DNA methyltransferase 3B (DNMT3B) gene contains a C-to-T single nucleotide polymorphism (SNP; rs2424913) in the Promotor region, 149 base pairs from the transcription start site, which is reported to significantly increase the Promotor activity.

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