Concurrent and Clonally Related Pediatric Follicular Lymphoma and Burkitt Lymphoma in a 5-Year-Old Boy | Zendy

Aaron C. Shaver | Zendy; David Zimmerman | Zendy; Mingya Liu | Zendy; Cindy L. VnencakJones | Zendy; Annette S. Kim | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Concurrent and Clonally Related Pediatric Follicular Lymphoma and Burkitt Lymphoma in a 5-Year-Old Boy

Author(s) -

Aaron C. Shaver,

David Zimmerman,

Mingya Liu,

Cindy L. VnencakJones,

Annette S. Kim

Publication year - 2016

Publication title -

laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.332

H-Index - 28

eISSN - 1943-7730

pISSN - 0007-5027

DOI - 10.1093/labmed/lmv014

Subject(s) - follicular lymphoma , lymphoma , chromosomal translocation , bcl10 , burkitt's lymphoma , follicular phase , medicine , pathology , cancer research , immunology , biology , oncology , gene , genetics

Pediatric follicular lymphoma shares morphologic similarities with the adult form of the disease but lacks other classic features of adult lymphoma, including t(14;18) translocation, BCL2 overexpression, and transformation to aggressive higher-grade lymphoma. Herein, we report a novel case in which a 5-year-old boy (ethnicity unknown) had follicular lymphoma, along with concurrent high-grade and clonally related disease that fulfilled all of the morphologic, immunophenotypic, and genetic criteria for Burkitt lymphoma, including a t(8;14) translocation involving the MYC gene. To our knowledge, this case is the first reported instance of transformation of follicular lymphoma of any sort into true Burkitt lymphoma and the first reported instance of acquisition of MYC abnormalities in pediatric follicular lymphoma.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research