Sudden Development of Thrombocytopenia After Reversal of Anticoagulation for Surgery | Zendy

Mobeen Rahman | Zendy; Ana Ortega-Lopez | Zendy; Amy Powers | Zendy

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Sudden Development of Thrombocytopenia After Reversal of Anticoagulation for Surgery

Author(s) -

Mobeen Rahman,

Ana Ortega-Lopez,

Amy Powers

Publication year - 2015

Publication title -

laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.332

H-Index - 28

eISSN - 1943-7730

pISSN - 0007-5027

DOI - 10.1093/labmed/lmv005

Subject(s) - medicine , platelet , heparin , antibody , heparin induced thrombocytopenia , warfarin , purpura (gastropod) , red cell , surgery , cardiology , anesthesia , immunology , atrial fibrillation , ecology , biology

Herein, we report a case of post-transfusion purpura after the reversal of anticoagulation for surgical purposes in a 66-year old ethnic Asian man who was undergoing long-term warfarin therapy for antiphospholipid syndrome. The patient experienced a sudden decrease in platelet count, from 308,000 per μL from the day of admission to 38,000 per μL the following day. Follow-up testing revealed unremarkable red blood cell (RBC) morphology, no evidence of platelet clumping, and negative heparin-induced antibody test results. Platelet antibody testing revealed anti-HPA15a antibodies.

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