Modified Proline Metabolism and Prolidase Enzyme in COVID-19 | Zendy

Merve Ergin Tunçay | Zendy; Salim Neşeli̇oğlu | Zendy; Emra Asfuroğlu Kalkan | Zendy; Osman İnan | Zendy; Meryem Sena Akkuş | Zendy; İhsan Ateş | Zendy; Özcan Erel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Modified Proline Metabolism and Prolidase Enzyme in COVID-19

Author(s) -

Merve Ergin Tunçay,

Salim Neşeli̇oğlu,

Emra Asfuroğlu Kalkan,

Osman İnan,

Meryem Sena Akkuş,

İhsan Ateş,

Özcan Erel

Publication year - 2022

Publication title -

laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.332

H-Index - 28

eISSN - 1943-7730

pISSN - 0007-5027

DOI - 10.1093/labmed/lmac017

Subject(s) - proline , hydroxyproline , metabolism , chemistry , enzyme , amino acid , biochemistry , medicine , endocrinology , biology

Objective The aim of the study was to evaluate proline metabolism in patients affected by COVID-19. Materials and Methods This case-control study consisted of 116 patients with COVID-19 and 46 healthy individuals. Tests related to proline metabolism (prolidase, proline, hydroxyproline, glutamic acid, manganese) and copper and zinc tests were analyzed. Results The levels of proline and hydroxyproline amino acids and the prolidase enzyme were found to be lower and glutamic acid was found to be higher in the COVID-19 group compared to the healthy group (P = .012, P < .001, P < .001, and P < .001, respectively). The copper/zinc ratio was higher in patients with COVID-19 than in healthy individuals (P < .001). Significant correlations were found between proline metabolism tests and inflammatory and hemostatic markers commonly used in COVID-19. Conclusion The proline metabolic pathway was affected in COVID-19. Relationships between proline pathway–related tests and inflammatory/hemostatic markers supported the roles of proline metabolism in proinflammatory and immune response processes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research