Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19 | Zendy

Bruna Lo Sasso | Zendy; Caterina Maria Gambino | Zendy; Nicola Scichilone | Zendy; Rosaria Vincenza Giglio | Zendy; Giulia Bivona | Zendy; Concetta Scazzone | Zendy; R Muratore | Zendy; Salvatore Milano | Zendy; Mario Barbagallo | Zendy; Luisa Agnello | Zendy; Marcello Ciaccio | Zendy

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Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19

Author(s) -

Bruna Lo Sasso,

Caterina Maria Gambino,

Nicola Scichilone,

Rosaria Vincenza Giglio,

Giulia Bivona,

Concetta Scazzone,

R Muratore,

Salvatore Milano,

Mario Barbagallo,

Luisa Agnello,

Marcello Ciaccio

Publication year - 2021

Publication title -

laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.332

H-Index - 28

eISSN - 1943-7730

pISSN - 0007-5027

DOI - 10.1093/labmed/lmab032

Subject(s) - interquartile range , medicine , covid-19 , biomarker , receiver operating characteristic , cutoff , pathology , biology , biochemistry , physics , disease , quantum mechanics , outbreak , infectious disease (medical specialty)

Objective The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19. Methods We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated. Results Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3–2.95 vs median, 0.82 nmol/L; interquartile range, 0.57–1.03; P <.0001). Receiver operating characteristic curve analysis showed good accuracy of MR-proADM for predicting mortality. A MR-proADM value of 1.73 nmol/L was established as the best cutoff value, with 90% sensitivity and 95% specificity (P <.0001). Conclusion We found that MR-proADM could represent a prognostic biomarker of COVID-19.

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