Association between decreased osteopontin and acute mountain sickness upon rapid ascent to 3500 m among young Chinese men | Zendy

Xu-Gang Tang | Zendy; Jing Wen | Zendy; Xuesen Zhang | Zendy; Da-Chun Jiang | Zendy

Open Access

Association between decreased osteopontin and acute mountain sickness upon rapid ascent to 3500 m among young Chinese men

Author(s) -

Xu-Gang Tang,

Jing Wen,

Xuesen Zhang,

Da-Chun Jiang

Publication year - 2018

Publication title -

journal of travel medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.985

H-Index - 59

eISSN - 1708-8305

pISSN - 1195-1982

DOI - 10.1093/jtm/tay075

Subject(s) - medicine , malondialdehyde , osteopontin , effects of high altitude on humans , superoxide dismutase , hypoxia (environmental) , odds ratio , altitude sickness , confidence interval , oxidative stress , altitude (triangle) , gastroenterology , endocrinology , oxygen , chemistry , geometry , mathematics , organic chemistry , anatomy

Hypoxia causes oxidative stress and a decrease in osteopontin (OPN) in rats; however, little is known about the change in OPN in lowlander humans during hypobaric hypoxia. We explore the role of the predicted decrease in plasma OPN levels in humans upon high-altitude exposure and its relationship with acute mountain sickness (AMS), as well as superoxide dismutase (SOD) and malondialdehyde (MDA).

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