How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry | Zendy

S. Sabater | Zendy; R. Berenguer | Zendy; Paloma HonrubiaGómez | Zendy; Miguel N. Rivera | Zendy; A. Núñez | Zendy; E. Jiménez-Jiménez | Zendy; A. Martos | Zendy; Carmen RamírezCastillejo | Zendy

Open Access

How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry

Author(s) -

S. Sabater,

R. Berenguer,

Paloma HonrubiaGómez,

Miguel N. Rivera,

A. Núñez,

E. Jiménez-Jiménez,

A. Martos,

Carmen RamírezCastillejo

Publication year - 2014

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1093/jrr/rru022

Subject(s) - radiation , monte carlo method , radiation dose , materials science , nuclear medicine , optics , mathematics , physics , statistics , medicine

Radiation of experimental culture cells on plates with various wells can cause a risk of underdosage as a result of the existence of multiple air-water interfaces. The objective of our study was to quantify this error in culture plates with multiple wells. Radiation conditions were simulated with the GAMOS code, based on the GEANT4 code, and this was compared with a simulation performed with PENELOPE and measured data. We observed a slight underdosage of ∼ 4% on the most superficial half of the culture medium. We believe that this underdosage does not have a significant effect on the dose received by culture cells deposited in a monolayer and adhered to the base of the wells.

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