Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells | Zendy

Mei Guo | Zendy; Zheng Dong | Zendy; Jie Qiao | Zendy; Yu Cheng | Zendy; Qiang Sun | Zendy; KaiXun Hu | Zendy; Guobin Liu | Zendy; Wei Liu | Zendy; Bo Yao | Zendy; Qiuhong Man | Zendy; Xuedong Sun | Zendy; Zhiqiang Liu | Zendy; Zheng-Qi Song | Zendy; Ye Chen | Zendy; Qiong Luo | Zendy; Shaofeng Liu | Zendy; Huashui Ai | Zendy

Open Access

Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells

Author(s) -

Mei Guo,

Zheng Dong,

Jie Qiao,

Yu Cheng,

Qiang Sun,

KaiXun Hu,

Guobin Liu,

Wei Liu,

Bo Yao,

Qiuhong Man,

Xuedong Sun,

Zhiqiang Liu,

Zheng-Qi Song,

Ye Chen,

Qiong Luo,

Shaofeng Liu,

Huashui Ai

Publication year - 2013

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1093/jrr/rrt102

Subject(s) - mesenchymal stem cell , stem cell , peripheral blood , medicine , acute radiation syndrome , transplantation , human leukocyte antigen , cancer research , immunology , biology , pathology , surgery , antigen , microbiology and biotechnology , haematopoiesis

This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy γ-radiation in a lethal (60)Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.

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