Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis | Zendy

Yifan Joshua Li | Zendy; Katalin A. Wilkinson | Zendy; Robert J. Wilkinson | Zendy; Anthony Figaji | Zendy; Ursula K. Rohlwink | Zendy

Open Access

Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis

Author(s) -

Yifan Joshua Li,

Katalin A. Wilkinson,

Robert J. Wilkinson,

Anthony Figaji,

Ursula K. Rohlwink

Publication year - 2019

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piy141

Subject(s) - medicine , tuberculous meningitis , cerebrospinal fluid , gelatinases , matrix metalloproteinase , meningitis , matrix metalloproteinase 9 , lumbar puncture , metalloproteinase , lumbar , pathology , tissue inhibitor of metalloproteinase , csf albumin , gelatinase , surgery

We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.

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