Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges | Zendy

Lara DanzigerIsakov | Zendy; Janet A. Englund | Zendy; Michael Green | Zendy; Klara M. PosfayBarbe | Zendy; Danielle M. Zerr | Zendy

Open Access

Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges

Author(s) -

Lara DanzigerIsakov,

Janet A. Englund,

Michael Green,

Klara M. PosfayBarbe,

Danielle M. Zerr

Publication year - 2018

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piy104

Subject(s) - medicine , cytomegalovirus , hematopoietic stem cell transplantation , transplantation , intensive care medicine , stem cell , hematopoietic cell , immunology , haematopoiesis , human immunodeficiency virus (hiv) , herpesviridae , viral disease , biology , genetics

Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation.

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