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Compromise of Second-Line Antiretroviral Therapy Due to High Rates of Human Immunodeficiency Virus Drug Resistance in Mozambican Treatment-Experienced Children With Virologic Failure
Author(s) -
Paula Vaz,
W Chris Buck,
Nilesh Bhatt,
Dulce Bila,
Andrew F. Auld,
James Houston,
Loide Cossa,
Charity Alfredo,
Kebba Jobarteh,
Jennifer Sabatier,
Eugénia Macassa,
Amina de Sousa,
Josh DeVos,
Ilesh Jani,
Chunfu Yang
Publication year - 2018
Publication title -
journal of the pediatric infectious diseases society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 31
eISSN - 2048-7207
pISSN - 2048-7193
DOI - 10.1093/jpids/piy102
Subject(s) - medicine , nevirapine , regimen , stavudine , lamivudine , viral load , immunosuppression , resistance mutation , pediatrics , drug resistance , immunology , antiretroviral therapy , human immunodeficiency virus (hiv) , virus , hepatitis b virus , reverse transcriptase , rna , biochemistry , chemistry , biology , microbiology and biotechnology , gene
Virologic failure (VF) is highly prevalent in sub-Saharan African children on antiretroviral therapy (ART) and is often associated with human immunodeficiency virus drug resistance (DR). Most children still lack access to routine viral load (VL) monitoring for early identification of treatment failure, with implications for the efficacy of second-line ART.

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