Serologic Detection of Antibodies Targeting the Leukocidin LukAB Strongly Predicts Staphylococcus aureus in Children With Invasive Infection | Zendy

James B. Wood | Zendy; Lauren Jones | Zendy; Nicole Soper | Zendy; Xu Meng | Zendy; Victor J. Torres | Zendy; C. Buddy Creech | Zendy; Isaac Thomsen | Zendy

Open Access

Serologic Detection of Antibodies Targeting the Leukocidin LukAB Strongly Predicts Staphylococcus aureus in Children With Invasive Infection

Author(s) -

James B. Wood,

Lauren Jones,

Nicole Soper,

Xu Meng,

Victor J. Torres,

C. Buddy Creech,

Isaac Thomsen

Publication year - 2018

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piy017

Subject(s) - medicine , staphylococcus aureus , leukocidin , serology , panton–valentine leukocidin , antibody , microbiology and biotechnology , virology , staphylococcal infections , immunology , methicillin resistant staphylococcus aureus , bacteria , biology , genetics

Staphylococcus aureus is among the most commonly identified causes of invasive bacterial infection in children; however, reliable results from cultures of sterile-site samples often cannot be obtained, which necessitates prescription of a broad empiric antimicrobial agent(s). Children with invasive S aureus infection rapidly generate high antibody titers to the cytotoxin LukAB; therefore, the aim of this study was to assess the diagnostic utility of an anti-LukAB antibody assay for children with musculoskeletal infection (MSKI).

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