Substituting Abacavir for Stavudine in Children Who Are Virally Suppressed Without Lipodystrophy: Randomized Clinical Trial in Johannesburg, South Africa | Zendy

Renate Strehlau | Zendy; Stephanie Shiau | Zendy; Stephen M. Arpadi | Zendy; Faeezah Patel | Zendy; Francoise Pinillos | Zendy; WeiYann Tsai | Zendy; Ashraf Coovadia | Zendy; Elaine J. Abrams | Zendy; Louise Kuhn | Zendy

Open Access

Substituting Abacavir for Stavudine in Children Who Are Virally Suppressed Without Lipodystrophy: Randomized Clinical Trial in Johannesburg, South Africa

Author(s) -

Renate Strehlau,

Stephanie Shiau,

Stephen M. Arpadi,

Faeezah Patel,

Francoise Pinillos,

WeiYann Tsai,

Ashraf Coovadia,

Elaine J. Abrams,

Louise Kuhn

Publication year - 2017

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/pix110

Subject(s) - medicine , abacavir , stavudine , lipodystrophy , randomized controlled trial , pediatrics , human immunodeficiency virus (hiv) , virology , antiretroviral therapy , viral load

Abacavir has replaced stavudine in antiretroviral therapy (ART) regimens because it has largely been phased out as a result of toxicity concerns; this loss has reduced further the already-limited drug options for children. Few data regarding virologic and metabolic outcomes among children who undergo substitution of stavudine exist. We evaluated the effects of preemptive substitution of abacavir for stavudine in children initially without lipodystrophy and virally suppressed on a stavudine-containing regimen.

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