Allograft Inflammatory Factor-1 Links T-Cell Activation, Interferon Response, and Macrophage Activation in Chronic Kawasaki Disease Arteritis | Zendy

Anne H. Rowley | Zendy; Susan C. Baker | Zendy; KwangYoun A. Kim | Zendy; Stanford T. Shulman | Zendy; Amy Yang | Zendy; David Arrollo | Zendy; Matthew DeBerge | Zendy; Shuling Han | Zendy; Nicholas E. S. Sibinga | Zendy; Adam J Pink | Zendy; Edward B. Thorp | Zendy

Open Access

Allograft Inflammatory Factor-1 Links T-Cell Activation, Interferon Response, and Macrophage Activation in Chronic Kawasaki Disease Arteritis

Author(s) -

Anne H. Rowley,

Susan C. Baker,

KwangYoun A. Kim,

Stanford T. Shulman,

Amy Yang,

David Arrollo,

Matthew DeBerge,

Shuling Han,

Nicholas E. S. Sibinga,

Adam J Pink,

Edward B. Thorp

Publication year - 2017

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/pix025

Subject(s) - medicine , kawasaki disease , immunology , macrophage activation syndrome , interferon , macrophage , takayasu's arteritis , vasculitis , disease , in vitro , biochemistry , chemistry , artery , arthritis

Kawasaki disease (KD) is widely viewed as an acute arteritis. However, our pathologic studies show that chronic coronary arteritis can persist long after disease onset and is closely linked with arterial stenosis. Transcriptome profiling of acute KD arteritis tissues revealed upregulation of T lymphocyte, type I interferon, and allograft inflammatory factor-1 (AIF1) genes. We determined whether these immune responses persist in chronic KD arteritis, and we investigated the role of AIF1 in these responses.

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