Evaluation of a Live Attenuated Human Metapneumovirus Vaccine in Adults and Children | Zendy

Ruth A. Karron | Zendy; Jocelyn San Mateo | Zendy; Kimberli Wanionek | Zendy; Peter L. Collins | Zendy; Ursula J. Buchholz | Zendy

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Evaluation of a Live Attenuated Human Metapneumovirus Vaccine in Adults and Children

Author(s) -

Ruth A. Karron,

Jocelyn San Mateo,

Kimberli Wanionek,

Peter L. Collins,

Ursula J. Buchholz

Publication year - 2017

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/pix006

Subject(s) - human metapneumovirus , medicine , metapneumovirus , vaccination , virology , population , pediatrics , immunology , respiratory tract infections , respiratory system , environmental health

We conducted a phase I clinical trial of an experimental live attenuated recombinant human metapneumovirus (HMPV) vaccine (rHMPV-Pa) sequentially in adults, HMPV-seropositive children, and HMPV-seronegative children, the target population for vaccination. rHMPV-Pa was appropriately restricted in replication in adults and HMPV-seropositive children but was overattenuated for HMPV-seronegative children.

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