Effectiveness of the 10-Valent Pneumococcal NontypeableHaemophilus influenzaeProtein D–Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media—A Double-Blind Randomized Clinical Trial in Finland | Zendy

Timo Vesikari | Zendy; Aino Forstén | Zendy; Ilkka Seppä | Zendy; Tarja Kaijalainen | Zendy; Taneli Puumalainen | Zendy; Anu Soininen | Zendy; Magali Traskine | Zendy; Patricia Lommel | Zendy; Sonia Schoonbroodt | Zendy; Marjan Hezareh | Zendy; Marta Moreira | Zendy; Dorota Borys | Zendy; Lode Schuerman | Zendy

Open Access

Effectiveness of the 10-Valent Pneumococcal NontypeableHaemophilus influenzaeProtein D–Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media—A Double-Blind Randomized Clinical Trial in Finland

Author(s) -

Timo Vesikari,

Aino Forstén,

Ilkka Seppä,

Tarja Kaijalainen,

Taneli Puumalainen,

Anu Soininen,

Magali Traskine,

Patricia Lommel,

Sonia Schoonbroodt,

Marjan Hezareh,

Marta Moreira,

Dorota Borys,

Lode Schuerman

Publication year - 2016

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piw010

Subject(s) - medicine , haemophilus influenzae , carriage , acute otitis media , microbiology and biotechnology , immunology , otitis , surgery , pathology , antibiotics , biology

After administering the 10-valent pneumococcal polysaccharide nontypeable Haemophilus influenzae protein D-conjugated vaccine (PHiD-CV) to children aged 2-18 months, we observed a reduction in vaccine-type nasopharyngeal carriage, resulting in a reduction of overall pneumococcal nasopharyngeal carriage, which may be important for indirect vaccine effects. We noted a trend toward reduction of acute otitis media.

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