Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis | Zendy

M.-L. Frémond | Zendy; Philippe Pérot | Zendy; Erika Muth | Zendy; Guilhem Cros | Zendy; Marine Dumarest | Zendy; Nizar Mahlaoui | Zendy; Danielle Seilhean | Zendy; Isabelle Desguerre | Zendy; C. Hébert | Zendy; Nicole Corre-Catelin | Zendy; Bénédicte Neven | Zendy; Marc Lecuit | Zendy; Stéphane Blanche | Zendy; Capucine Pïcard | Zendy; Marc Éloit | Zendy

Open Access

Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis

Author(s) -

M.-L. Frémond,

Philippe Pérot,

Erika Muth,

Guilhem Cros,

Marine Dumarest,

Nizar Mahlaoui,

Danielle Seilhean,

Isabelle Desguerre,

C. Hébert,

Nicole Corre-Catelin,

Bénédicte Neven,

Marc Lecuit,

Stéphane Blanche,

Capucine Pïcard,

Marc Éloit

Publication year - 2015

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piv040

Subject(s) - medicine , astrovirus , brain biopsy , cerebrospinal fluid , encephalitis , dna sequencing , virology , polymerase chain reaction , biopsy , pediatrics , pathology , virus , genetics , gene , biology , rotavirus

A boy with X-linked agammaglobulinemia experienced progressive global motor decline, cerebellar syndrome, and epilepsy. All standard polymerase chain reactions for neurotropic viruses were negative on cerebrospinal fluid and brain biopsy. Next-generation sequencing allowed fast identification of a new astrovirus strain (HAstV-VA1/HMO-C-PA), which led to tailor the patient's treatment, with encouraging clinical monitoring over 1 year.

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