T-Regulatory Cells and Inflammatory and Inhibitory Cytokines in Malawian Children Residing in an Area of High and an Area of Low Malaria Transmission During Acute Uncomplicated Malaria and in Convalescence | Zendy

Tonney S. Nyirenda | Zendy; Malcolm E. Molyneux | Zendy; Rupert Kenefeck | Zendy; Lucy S. K. Walker | Zendy; Calman A. MacLennan | Zendy; Robert S. Heyderman | Zendy; Wilson L. Mandala | Zendy

Open Access

T-Regulatory Cells and Inflammatory and Inhibitory Cytokines in Malawian Children Residing in an Area of High and an Area of Low Malaria Transmission During Acute Uncomplicated Malaria and in Convalescence

Author(s) -

Tonney S. Nyirenda,

Malcolm E. Molyneux,

Rupert Kenefeck,

Lucy S. K. Walker,

Calman A. MacLennan,

Robert S. Heyderman,

Wilson L. Mandala

Publication year - 2015

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piu140

Subject(s) - convalescence , malaria , medicine , parasitemia , immunology , transmission (telecommunications) , immune system , plasmodium falciparum , electrical engineering , engineering

Malaria still infects many Malawian children, and it is a cause of death in some of them. Regulatory T cells (Tregs) help in negating immune-related pathology, it but can also favor multiplication of malaria parasites. The question remains whether children recovering from uncomplicated malaria (UCM) have higher Tregs and interleukin (IL)-10 levels in convalescence.

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