Plague in a Pediatric Patient: Case Report and Use of Polymerase Chain Reaction as a Diagnostic Aid | Zendy

Wendi K. Drummond | Zendy; Christina A. Nelson | Zendy; J R Fowler | Zendy; Erin Epson | Zendy; Paul S. Mead | Zendy; Elisabeth Lawaczeck | Zendy

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Plague in a Pediatric Patient: Case Report and Use of Polymerase Chain Reaction as a Diagnostic Aid

Author(s) -

Wendi K. Drummond,

Christina A. Nelson,

J R Fowler,

Erin Epson,

Paul S. Mead,

Elisabeth Lawaczeck

Publication year - 2014

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piu001

Subject(s) - medicine , yersinia pestis , septic shock , polymerase chain reaction , plague (disease) , vomiting , intensive care medicine , antimicrobial , virology , pediatrics , immunology , surgery , pathology , microbiology and biotechnology , sepsis , biochemistry , chemistry , virulence , biology , gene

We report a case of bubonic plaque in a 7-year-old patient who presented with a core temperature of 107°F, seizures, vomiting, altered mental status, and septic shock. This case highlights the utility of polymerase chain reaction (PCR) as a diagnostic aid for rapid presumptive identification of Yersinia pestis as well as the importance of correlating PCR results with clinical data. We discuss the various manifestations of plague as they relate to infection control, postexposure prophylaxis, antimicrobial therapy, and treatment duration.

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