Characterization of the Acute Inflammatory Response in Measles Infection | Zendy

Jaap ten Oever | Zendy; Anca Riza | Zendy; Mihaela Sabou | Zendy; Cristina Cismaru | Zendy; Mihai G. Netea | Zendy; Adriana Slavcovici | Zendy

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Characterization of the Acute Inflammatory Response in Measles Infection

Author(s) -

Jaap ten Oever,

Anca Riza,

Mihaela Sabou,

Cristina Cismaru,

Mihai G. Netea,

Adriana Slavcovici

Publication year - 2013

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/pit082

Subject(s) - medicine , immunology , measles , leukopenia , inflammatory response , interferon , interleukin , inflammation , cytokine , virology , vaccination , chemotherapy

Among 167 hospitalized children with measles, circulating concentrations of interleukin (IL)-6, IL-1β, IL-1Ra, IL-4, interferon (IFN)-α, IFN-β, and T helper-17 cytokines were low, whereas leukopenia, increased lactate dehydrogenase, IL-18, and IFN-γ concentrations characterized the inflammatory response. In addition to understanding measles-induced immunologic responses, this profile may assist in differential diagnosis.

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